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It has likely won more games per deck inclusion than any card on this list too

(In other words, it doesn't just mean "protection from objects that have all five colors.") (2011-01-01)

Honorable Mention #2 (#13 Overall)

Enchanted creature gets +2/+2

It can't be enchanted by or equipped with cards of that colour either, and if a creature already has an equipment or enchantment on it, and then gets protection from their colour or type, that equipment or enchantment will fall off

Animate Dead is truly one of the best reanimation effects ever printed, and the ability to return Creatures from an opponents graveyard is a nice bonus