Alice Growing Girl provides all other characters with Support and also gains 4 Lore if it has Strength of 10 or more
They are great at fighting bigger creatures, thanks to usually having deathtouch
Vampires are able to make each other stronger through 'Lord' abilities, giving each other stat buffs or even putting permanent +1/+1 counters on each other
Those mana sinks are both useful and powerful, and attacking with a modified creature isnt much of a hoop to jump through
As your opponents creatures fall, Sephiroth will gain power, eventually becoming strong enough to take on anything on the board
Wheel cards often make you discard your own cards as well, so when paired with cards with madness, this can lead to easy casting of your spells thanks to the alternate costs