Anubis uses a Proof-of-Work scheme in the vein of Hashcash, a proposed proof-of-work scheme for reducing email spam
Normally, The Sixth Doctor costs a bit of mana to cast, but with Amazing Spider-Man, you can get The Sixth Doctor down on the battlefield for only three mana, letting you take advantage of its effect during the early stages of the game
Ezuri, Stalker of Spheres is a strong roleplayer in Proliferate decks, and could make for a fun Commander
Necropotence essentially, at the very low cost of 'cards that are discarded get exiled', swaps your regular draw phase for 'pay X life, draw X cards next turn'
That means it burns out quick if interacted with, but both Reveillark and Vesperlark can help you recover from a blowout
I'm talking, of course, about spoiler season for the Arena-exclusive MTG Spider-Man cards