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Product Name Mal-Propionyl-Beta-Ala-Val-Ala-PAB(m-PEG8)-MMAE Synonyms CAS Number Related CAS Molecular Formula C83H133N11O24 Molecular Weight 1669
653 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCCNC(=O)CCN2C(=O)C=CC2=O)CCN(CC(O)=O)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
The conjugate has better solubility than the parent dye carboxyrhodamine and its long PEG spacer should reduce any steric effect of the dye on the molecule to be labelled
293 Purity (HPLC) >= 95% Solubility DMSO
Product Name Azide-Lys(m-PEG4)-Gly-Gly-Phe-Gly-PAB-PNP Synonyms CAS Number Related CAS Molecular Formula C45H59N11O14 Molecular Weight 978
Mal-Propionyl-PEG4-Val-Ala-PAB(m-PEG4)-MMAE carboxylic ester Product Name Mal-Propionyl-Beta-Ala-Val-Ala-PAB(m-PEG8)-MMAE Synonyms CASSOLU KNEX cleavable linker features a Val Ala dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG4 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly
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