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VHL-SNAP2-5C is a SNAP PROteolysis TArgeting Chimera (SNAP-PROTAC)
S)-AHPC-acetamido-O-PEG5-C1-acid Synonyms CAS Number 2361117-11-3 Related CAS Molecular Formula C36H54N4O12S Molecular Weight 766
SHP099 is a highly potent (IC50 = 0
85 SMILES: Cl
367 SMILES OCCCCCC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
Mal-Propionyl-PEG8-Gly-Gly-Phe-Gly-PAB(m-PEG4) deuterium-labeled-amine VHL-SNAP2-5C is a SNAP PROteolysisSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG8 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. Derived from established ADC linker
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