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Product Name DBCO-Dap(m-PEG4)-Val-Ala-PAB(m-PEG8)-Exatecan Synonyms CAS Number Related CAS Molecular Formula C90H115FN10O25 Molecular Weight 1755
33 Purity (HPLC) >= 95% Solubility DMSO
411 SMILES OCCCCCCC1=CC=C2C(=O)N(CC2=C1)C1CCC(=O)NC1=O Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
265 SMILES NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
SHP099 suppresses RAS–ERK signalling to inhibit the proliferation of receptor-tyrosine-kinase-driven human cancer cells in vitro and is efficacious in mouse tumour xenograft models
Azide-Propionyl-Val-Cit-PAB(m-PEG8) ca Product Name DBCO-Dap(m-PEG4)-Val-Ala-PAB(m-PEG8)-Exatecan Synonyms CASSOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine containing groups, or polysarcosine (PSAR), to enhance aqueous solubility. Solubility and physicochemical properties can be finely tuned through selection
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