Azide-Propionyl-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan dbco-hexanoyl 366 SMILES OCCOCCCC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)

366 SMILES OCCOCCCC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name DBCO-Lys(m-PEG4)-Val-Cit-PAB(m-PEG4) Synonyms CAS Number Related CAS Molecular Formula C63H91N9O17 Molecular Weight 1246

Product Name Mal-Propiony-Beta-Ala-Gly-Gly-Phe-Gly-PAB(m-PEG8) Synonyms CAS Number Related CAS Molecular Formula C50H72N8O18 Molecular Weight 1073

Product Name Lenalidomide-PEG2-OH Synonyms Lenalidomide-4'-PEG2-OH CAS Number n/a Related CAS Molecular Formula C17H21N3O5 Molecular Weight 347

Product Name DOTA-tris(t-Bu)ester-C6-acid Synonyms CAS Number n/a Related CAS Molecular Formula C35H65N5O9 Molecular Weight 699

Azide-Propionyl-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan dbco-hexanoyl 366 SMILES OCCOCCCC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)SOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU