Mal-Propionyl-PEG2-Val-Cit-PAB(m-PEG8)-PNP mal-hexanoyl Product Name Azide-Dap(m-PEG4)-Val-Ala-PAB(m-PEG4)-Exatecan Synonyms CAS

Product Name Azide-Dap(m-PEG4)-Val-Ala-PAB(m-PEG4)-Exatecan Synonyms CAS Number Related CAS Molecular Formula C63H84FN11O19 Molecular Weight 1318

557 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCCCN=[N+]=[N-])CCN(CC(O)=O)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Nature 2020

HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation

Product Name 1-(methyl-d3)-2

Mal-Propionyl-PEG2-Val-Cit-PAB(m-PEG8)-PNP mal-hexanoyl Product Name Azide-Dap(m-PEG4)-Val-Ala-PAB(m-PEG4)-Exatecan Synonyms CASSOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG2 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The PNP (para nitrophenyl) moiety serves as an activating