Yes, you can exile an indestructible permanent, be it a creature, artifact, enchantment, or land
This can be a helpful way of quickly drawing cards when you need to, but has especially exciting potential when combined with other amethyst Rise of the Floodborn cards that trigger effects as they leave play - letting you yoink them off the field using Yzma, Scary Beyond All Reason, activate their own powers and then draw two cards, all in a single play
But everything is more complex
If you wanted to go full time well you probably need a lot of capital to start with
Not only did I see him as a viable commander, including my revisions featured in my last article, but I saw enough versatility that I built three articles around him as: a clone deck, a poison deck, and a sliver deck back in the fall of 2019
Spike Feeder + Archangel of Thune This combo saw some play in Modern, but it takes a while to start and is relatively easy to prevent