1st edition metazoo booster box CCG: Wilderness: and sky MetaZoo TCG: 2nd Edition Cryptid

You can argue about every other placement on this list, and I'm confident that in a vote I would be in the minority on what deserves the two slot, but no one thinks this is anything but Black Lotus

4 Unova (Gen 5) The Unova region in Pokemon Black & White has the honor of having one of the toughest Elite Fours in the franchise's history, albeit one of the least memorable selections of characters

The set characters, items, and places from all 16 of the mainline games

The Duelists of the Roses use their own passwords for cards

2 Pokmon TCG:Booster Packs: - 1 Obsidian Flames Booster Pack

That's why it should be in every serious Pokemon collector's collection