Creatures with the Persist ability come back from the graveyard after they are destroyed if they have no counters on them, and then receive a -1/-1 counter upon their return
This is well represented in the game mechanics for the best sapphire cards in Rise of the Floodborn, as many of them are designed to give players more options
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Its "Vanish" ability lets you banish an opponent if Giant Cobra is chosen for an action, and its "Mysterious Advantage" lets you choose and discard a card for 2 lore when you first play this card
Cait Sith, Fortune Teller gives you that effect in general to whatever creature you like and throws in a cheeky scry as well for your trouble
There are also plenty of cool surprises and some incredibly powerful abilities and combos