Human B7-H3 Mouse IgG2a Wildtype Fc Amount:50 µg Osteopetrosis is a rare genetic

Osteopetrosis is a rare genetic disease characterized by abnormally dense bone

4-1BBL can promote CD8 T cell expansion as well as protect against autoimmune and transplantation rejection

as well as Etanercept (Enbrel) which is a decoy protein consisting of the TNFR2 extracellular domain fused an Ig Fc region

Mechetina LV

1038/s41577-022-00821-1

Human B7-H3 Mouse IgG2a Wildtype Fc Amount:50 µg Osteopetrosis is a rare geneticB7 H3 is an orphan ligand in the B7 family. Its extended extracellular IgSF domain is unique within the family and is phylogenically found in primates only. B7 H3 is known as a co stimulatory and co inhibitory ligand, even though most studies indicate B7 H3 acts as an inhibitor for T cells functions. Consistent with the inhibitory notion, B7 H3 null mice exhibits an earlier onset of autoimmune disorders. P7105F contains all four extracellular IgV C